When trying my hand (fleet) in challenge 4578387, and after at least 5-10 minutes slugfest, the tides were reversing and I wasn’t pounded into space dust, GSB crashed.
Screenshot attached (The black area was due to GSB not redrawing post-crash when I temporarily had another window over it).
I suspect this has something to do with the amount of shots fired, as this challenge simply has a ridiculous amount of missile spammage (for which the swarm has the ultimate answer).
Machine: Intel C2D E8550, Asus P5B, 8GB PC6400, Sapphire HD5770 Vapor-X, Asus Xonar D2X
OS: Windows 7 Ultimate x64