Further ingredient types, cures and side-effects, with ingredients starting at a higher tier (Like at Eases Asthma), new tier side effects that might need more to remove, maybe a catalyst to remove, or ‘upgrading/downgrading’ of side effects (Prompts Sleepiness > Induces Nightmares > Induces Coma), and you may have to downgrade it to completely remove it’s effects? I’d leave the design choices to be more thoroughly discussed by others. Just some ideas I’d like to throw out. Space exploration, rocks and minerals from the Lunar surface or asteroids, more rocks and minerals from deeper in the planet. Just in general game extension.