I’m running OS X 10.9.5 on a late 2012 Mac Mini and ran into some graphical difficulties with the settings given in the original video, probably based on the different video chipset and/or OS version. I did confirm that I’m using the same Wineskin Winery Engine version (WS9Wine1.7.44) and Wrapper (Wineskin-2.6.0) as in the video.
For me, to get the machines, factory floor, factory walls, etc. to display I had to use settings of:
WINE SCREEN OPTIONS:
Force Normal Windows
Decorate Windows (checked)
Auto Detect GPU Info for Direct3D (checked)
BIG PHARMA OPTIONS:
1920x1080 (real resolution, which gets changed to 1920x1058 automatically)
MAC OS DOCK:
Turn Hiding On (because the dock sits on top of the game screen)
If I out of the program and re-enter it will refresh the display and show the factory correctly with the machines. I also had to do this tab out to get the initial window with the initial upgrade button to show correctly. In the game, things like the ingredient and pill overlay for wall input/output nodes are still invisible but present (you can click on them if you know where they should be and watch for the cursor change), and the purchase button for factory tiles is also invisible (but also clickable when the cursor changes). The game is very playable despite the invisible overlays, needing to tab out and back to get the factory map to refresh, and needing to turn Hiding on for the Dock so it doesn’t sit on top of the game screen.
I cannot wait until it is released for real for OS X.