Race for the Cure
The VIP Trip. The president is dying of a high-level disease. Everything is researched, but we need a treatment that cures X, and we need it within the month. Also, we only have this tiny space to work in. The business challenge goes out the window in exchange for an unusual complication: the fewest total steps possible, regardless of cost.
The Philospher’s Stone. All of the catalysts are available in one and only one ingredient.
Don’t say the Z-word. Raving infectees are causing chaos everywhere! Develop a cure with X,Y, and Z effects! You start with a supply of explorers and scientists, but they randomly disappear and can’t be replaced!
Packing Problems. Develop a top-tier cure within X years. Only one factory is available. Similar to VIP Trip, except more time is available and you need to produce more than one batch.
Lol Dissolvers are for newbs. Dissolvers, Evaporators, and pill presses aren’t available, but you start with Ionizers, aglomerizers, and creamers.
Dank Nugs: Everything is legal, including selling sugar pills with maximum-strength hallucinations as a “side effect.” Some side effects have a positive value in this mode.
Sandbox: everything is unlocked, there’s no goal, and you can’t run out of money. Finally test those crazy production lines you’ve been thinking of!