You need to reduce the Concentration to 7-11 then put it through the dissolver.
So as follows.
13 at start.
10 after ionizer. (Now it can be upgraded)
9 after Dissolver. (Now it should upgrade to ADHD)
In other words - You need to get the “green hoke” and THEN run it through the machine it needs to upgrade - It can’t upgrade the ingredient until it’s “ticked green” beforehand.
Example: An ingredient with 13 starting concentration needs a range of 7-10 and an Ionizer to upgrade to Heart Stroke medicine. I can’t just put it through a single Ionizer to upgrade it, because it wasn’t at 10 or less before it went into the machine. I’d have to put it through two - One to reduce the concentration to the Upgrade requirement, and then another upgrade it for real.
Also remember that some cures require a catalyst to be upgraded - The green icon with two balls connected by a line, or the blue triangle ball icon. These come from Side Effects in ingredients - If your ingredient doesn’t have one of those already, you need to use the Multimixer (and possibly) Shaker to mix it into it.
If you’re still confused take a screenshot (print screen button) and CTRL+V it in Paint and save it online somewhere so I can take a look at what the requirements are and what you are possibly doing wrong.