I was just thinking it would be cool to have a Gratuitous Space Battles meets Starship Tycoon! Starship Tycoon 2 - Grandiose Space Fleets!??
You would be the commander of a space fleet which you can build and modify like GSB but you send your starships on missions to carry cargo/passengers/fight pirates through space routes with different dangers and requirements each turn to build your tycoon empire! You can fine tune your ships to perform better each run to get better returns. You would have to mod your ship to fight off pirates, streamline your speed and travel efficiency, carry more cargo and different types of cargo (different alien livestock and species, dilithium isotopes, passengers, etc), change to tractor beams navigate asteroid belts runs like ice breakers, get warp engines to travel greater distances or solar sails for more efficiency, etc.
Space is a dangerous place! But it is the galaxy of opportunity for those who take it! You are the commander of a shipping starfleet making runs through space to gain creds on runs to build your galactic empire!